Perioperative medicine & outcomes
The association between frailty and ageing: Results from an observational study including 9497 elderly patients
Primary result · FrailtyResult — go to the resultOdds ratio 2.6 95% CI 2.3–3.1Authors' conclusion
We found a high frequency of frailty in patients aged 90 years or above compared with patients aged 80-89. In addition, frailty was associated with an increased risk of 30-day mortality. Surprisingly, age was not a significant risk factor in the adjusted mortality analysis.
Study context
- Population
- Patients ≥80 years undergoing any surgical and nonsurgical procedures in 177 European centres, October 2017 to December 2018
- Participants
- 9,497 patients · 177 European centres
- Comparison
- Patients ≥90 years vs patients aged 80-89
- ≥90 yearsn = 999
- Primary endpoint
- Prevalence of frailty (binary variable)
Methodological detailsplanned secondary analysis, multicentre
- Planned secondary analysis
- Multicentre
Primary result
Frailty
Odds ratio
2.6
95% CI 2.3–3.1
Events by treatment group
≥90 years vs 80-89
OR 2.6 (95% CI 2.3–3.1)
As reported in the abstract
Further findings
| Outcome | Estimate | |
|---|---|---|
| All-cause 30-day mortality, frail vs not frail · unadjusted | crude OR 6.3 (CI 5.1–7.7) | |
| All-cause 30-day mortality, frail vs not frail | OR 4.5 (CI 3.6–5.7) | |
| 0.10.31310Ratio (log scale) |
- All-cause 30-day mortality, frail vs not frail: adjusted for age, sex, surgical urgency, orthopaedic urgency, surgical severity
All-cause 30-day mortality, age ≥90 (adjusted analysis)
- Age ≥90 not associated with 30-day mortality in the adjusted analysis
Original publication
The association between frailty and ageing: Results from an observational study including 9497 elderly patients. Acta Anaesthesiol Scand. Published 21 November 2023. doi:10.
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