The association between labour epidural analgesia and postpartum depression in primiparous patients: a historical cohort study
Main finding · PPDResult — go to the resultAdjusted odds ratio 1.29 95% CI 1.12–1.48Authors' conclusion
This historical cohort study found an association between LEA and PPD among primiparous patients who subsequently had a second pregnancy in the same province.
Study context
- Population
- Primiparous patients who delivered a liveborn singleton infant between 2004 and 2018 and had a second pregnancy in the same province
- Participants
- 35,437 patients
- Exposure
- Labour epidural analgesia (LEA) vs no LEA
- LEAn = 23,599
- Outcome
- PPD following first delivery (history of PPD in perinatal records of second pregnancy)
Methodological detailsprovincial perinatal database, adjusted analysis
- Provincial perinatal database
- Adjusted analysis
Main finding
PPD
Adjusted odds ratio
1.29
95% CI 1.12–1.48
LEA vs No LEA
aOR 1.29 (95% CI 1.12–1.48)
As reported in the abstract
- PPD in the cohort
- 3.7% (n = 1,296)
Observational data: associations, not effects.
Further findings
Predictors of PPD (multivariable regression)
- LEA remained a significant predictor for PPD, as did BMI, pre-existing anxiety and maternal antidepressant use
Original publication
The association between labour epidural analgesia and postpartum depression in primiparous patients: a historical cohort study. Can J Anaesth. Published 19 September 2023. doi:10.
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