Sepsis & infection

The Association Between Socioeconomic Position and Mortality in Patients With Sepsis and Septic Shock—A Systematic Review and Meta-Analysis

Crit Care MedPublished Systematic review and meta-analysis of observational studies

Authors' conclusion

We found that several indicators of SEP were associated with increased short-term mortality in patients with sepsis and septic shock.

Study context

Population
Adults with sepsis and/or septic shock
Participants
3,951,677 adults · 13 observational studies
Comparison
Lower vs higher socioeconomic position
Outcome
Mortality
Methodological detailsrandom-effects models, GRADE certainty assessment, QUIPS risk-of-bias assessment
  • Random-effects models
  • GRADE certainty assessment
  • QUIPS risk-of-bias assessment

Pooled result

As reported in the abstract

Mortality by SEP indicator
Estimate (95% CI)
Lack of private insurancehigh certainty
aOR 1.34(1.19–1.51)
Lower neighborhood socioeconomic statusmoderate certainty
aOR 1.35(1.29–1.41)
Lower incomemoderate certainty
aOR 1.06(1.01–1.11)
Lower incomemoderate certainty
aHR 1.51(1.01–2.25)
Less educationlow certainty
aOR 1.33(1.14–1.55)
Unemploymentlow certainty
aOR 1.91(1.00–3.63)

Original publication

The Association Between Socioeconomic Position and Mortality in Patients With Sepsis and Septic Shock—A Systematic Review and Meta-Analysis. Crit Care Med. Published 20 March 2026. doi:10.1097/ccm.0000000000007053

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