ICU sedation, delirium & recovery
The association of premorbid conditions with 6-month mortality in acutely admitted ICU patients over 80 years
Authors' conclusion
We found that Clinical Frailty Scale, age, and SOFA at admission were independent prognostic factors for 6 month mortality after ICU admission in patients age 80 and above. Adding other geriatric syndromes and scores did not improve the model.
Study context
- Population
- Patients ≥ 80 years with emergency (acute) ICU admission, 242 ICUs in 22 countries, May 2018–May 2019; planned/elective surgical admissions excluded
- Participants
- 3,920 patients · 242 ICUs · 22 countries
- Exposure
- 6-month survivors vs non-survivors
- Outcome
- Mortality
- Follow-up
- 6 months
Methodological detailsmulticentre, international
- Multicentre
- International
Main finding
As reported in the abstract
6-month mortality
6-month mortality
64%
Died during ICU stay
1191
30.9%
Died after ICU discharge within 30 days
436
11.1%
Died after 30 days within 6 months
895
22.8%
Observational data: associations, not effects.
Further findings
Frailty (CFS > 5)
P < 0.01
| Outcome | SurvivorsMedian | Non-survivors | P value |
|---|---|---|---|
| AgeSurvivors slightly younger | 84 (IQR 81–86) | median 84 (IQR 82–87) | P = 0.013 |
| Katz ADL scoreSurvivors less dependent | 6 (IQR 5–6) | median 6 (IQR 3–6) points | P < 0.01 |
Premorbid conditions, whole cohort
- Median Clinical Frailty Scale (CFS) (IQR)
- 4 (3-6)
- Frailty (CFS ≥ 5)
- 26.6%
- Cognitive decline (Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) above 3.5)
- 30.2%
- Median IQCODE
- 3.19
- Katz activities of daily living (ADL) of 4 or less
- 27.7%
Original publication
The association of premorbid conditions with 6-month mortality in acutely admitted ICU patients over 80 years. Ann Intensive Care. Published 30 March 2024. doi:10.
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