ICU sedation, delirium & recovery
The role of clinical phenotypes in decisions to limit life-sustaining treatment for very old patients in the intensive care unit (ICU)
Authors' conclusion
Clinical phenotypes on ICU admission predict limitations of LST in the context of cultural norms (country).
Study context
- Population
- Patients aged 80 years or older admitted to ICUs in 22 countriesassigned to one of seven phenotypes
- Participants
- 1,268 patients
- Comparison
- Seven clinical phenotypes on ICU admission and decisions to limit life-sustaining treatment (LST)
- Primary endpoint
- Decisions to limit LST (withhold or withdraw) in the ICU
Methodological detailsmultinational (22 countries), clustering analysis
- Multinational (22 countries)
- Clustering analysis
Primary result
As reported in the abstract
Limitation of LST
Incidence of decisions to withhold LST
26.5%
Incidence of decisions to withdraw LST
8.1%
Further findings
Prediction of limitations of LST (logistic regression models)
- Best discriminatory performance after combining phenotype, ventilatory support and country
Original publication
The role of clinical phenotypes in decisions to limit life-sustaining treatment for very old patients in the ICU. Ann Intensive Care. Published 10 May 2023. doi:10.
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