Perioperative medicine & outcomes
The Association of Preoperative Diabetes With Postoperative Delirium in Older Patients Undergoing Major Orthopedic Surgery: A Prospective Matched Cohort Study
Main findingResult — go to the resultOdds ratio 3.2 95% CI 1.4–8.0Authors' conclusion
This study suggests that preoperative diabetes is associated with an increased risk of POD in older patients undergoing major orthopedic surgery, and that low intraoperative alpha power partially mediates such association.
Study context
- Population
- Patients aged 60 years or more undergoing elective major orthopedic surgery138 matched pairs
- Participants
- 132 vs 134
- Exposure
- Preoperative diabetes vs no diabetes
- Diabetesn = 132
- Nondiabetesn = 134reference
- Outcome
- Occurrence of POD (3D-CAM, once daily)
- Follow-up
- Postoperative days 1-7 or until discharge
Methodological detailsmatched 1:1 (age, sex, type of surgery), mediation analysis
- Matched 1:1 (age, sex, type of surgery)
- Mediation analysis
Main finding
As reported in the abstract
Odds ratio
3.2
95% CI 1.4–8.0
P = 0.009
Events by group
Diabetes vs Nondiabetes
OR 3.2 (95% CI 1.4–8.0); P = 0.009
Observational data: associations, not effects.
Secondary outcomes
Proportion of diabetes–postoperative delirium (POD) association mediated by intraoperative alpha power
- Proportion mediated
- 20% (95% CI, 2.6-60%; P = .021)
Original publication
The Association of Preoperative Diabetes With Postoperative Delirium in Older Patients Undergoing Major Orthopedic Surgery: A Prospective Matched Cohort Study. Anesth Analg. Published 9 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →