Pediatric anesthesia & critical care
The Association of Preoperative Hydrocodone and Acetaminophen With Total Opioid Requirement, and Pain Experience in Children Undergoing Adenotonsillectomy
Authors' conclusion
Pre-operative hydrocodone with acetaminophen was associated with improved outcomes with respect to PACU pain experience and time to discharge. The total OME increase was limited to the pre-operative HA dose.
Study context
- Population
- Children undergoing adenotonsillectomy at Texas Children's Hospital, 11/2017–12/2018
- Participants
- 1,082 children
- Exposure
- Preoperative hydrocodone with acetaminophen vs no preoperative HA
- HAn = 366
- Outcome
- Total perioperative opioid consumption as oral morphine equivalents (OME)
Methodological detailssingle-centre, multivariable linear regression
- Single-centre
- Multivariable linear regression
Main finding
As reported in the abstract
Total intraoperative and postoperative OME
P = 0.56
Observational data: associations, not effects.
Secondary outcomes
Median, min
| Outcome | HA | Control | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| PACU discharge timePACU discharge time exceeding 30 min | 30.0 (IQR 20.0–46.0) | 39.0 (IQR 25.0–58.0) | 0.39 (0.28–0.54) | P < 0.001 | |
| Maximal PACU pain score 0-3 | 2.16 (1.56–2.99) | P < 0.001 | |||
| Maximum PACU pain score of zero | 1.85 (1.34–2.56) | P < 0.001 | |||
| 0.20.5125Odds ratio (log scale) |
Original publication
The Association of Preoperative Hydrocodone and Acetaminophen With Total Opioid Requirement, and Pain Experience in Children Undergoing Adenotonsillectomy. Acta Anaesthesiol Scand. Published 24 July 2025. doi:10.
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