The effect of high protein dosing in critically ill patients: an exploratory, secondary Bayesian analyses of the EFFORT Protein trial
Primary result · 60-day all-cause mortalityResult — go to the resultAbsolute difference 2.5 % points 95% CrI −6.9 to 12.4Authors' conclusion
We found moderate to high probabilities of harm with high protein doses compared with usual protein in ICU patients for the primary and secondary outcomes.
Study context
- Population
- Adult ICU patients with organ failure
- Comparison
- High vs usual protein dosing
Methodological detailsexploratory, weakly informative priors
- Exploratory
- Weakly informative priors
Primary result
60-day all-cause mortality · 60 days
Absolute difference
2.5 % points
95% CrI −6.9 to 12.4
High protein vs Usual protein
absolute difference 2.5 % points (95% CrI −6.9 to 12.4)
As reported in the abstract
Secondary outcomes
| Outcome | HR (95% CrI) | |
|---|---|---|
| Time to discharge alive from hospitalCrI; 92% probability of harm · CrI | 0.91 (0.80–1.04) | |
| 0.512Hazard ratio (log scale) |
Heterogeneity in treatment effects (HTE) on mortality by baseline serum creatinine and SOFA score (subgroup)
- Probability of positive interaction with serum creatinine
- 97%
- Probability of positive interaction with SOFA score
- 95%
- Potentially relatively higher mortality of high protein doses with higher baseline serum creatinine or SOFA scores
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The effect of high protein dosing in critically ill patients: an exploratory, secondary Bayesian analyses of the EFFORT Protein trial. Br J Anaesth. Published 24 October 2024. doi:10.
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