Perioperative medicine & outcomes
The Effect of Perioperative Dexamethasone on Postoperative Complications After Pancreaticoduodenectomy: A Multicenter Randomized Controlled Trial
Primary resultResult — go to the resultMean difference −3.8 95% CI −8.4 to 0.7Authors' conclusion
Perioperative dexamethasone did not significantly reduce postoperative complications within 30 days after pancreaticoduodenectomy.
Study context
- Population
- Adults undergoing elective pancreaticoduodenectomy, four Chinese high-volume pancreatic centers265 in modified ITT analysis
- Participants
- 300 adults
- Comparison
- Dexamethasone 0.2 mg/kg IV vs saline placebo after anaesthesia induction
- Dexamethasonen = 134
- Placebon = 131reference
- Primary endpoint
- Comprehensive Complication Index (CCI) score
- Follow-up
- Within 30 days after the operation
Methodological detailsmulticentre, double-blind, placebo-controlled
- Multicentre
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Mean difference
−3.8
95% CI −8.4 to 0.7
P = 0.100
By group
Dexamethasone
14.0
mean · SD 17.5
Placebo
17.9
mean · SD 20.3
Dexamethasone vs Placebo
mean difference −3.8 (95% CI −8.4 to 0.7); P = 0.100
Further findings
| Outcome | Dexamethasone | Placebo | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Major complications (Clavien-Dindo grade ≥III) | 12.7% | 16.0% | 0.79 (0.44–1.43) | P = 0.439 | |
| Postoperative pancreatic fistula | 25.4% | 31.3% | 0.81 (0.55–1.19) | P = 0.286 | |
| 0.512Relative risk (log scale) |
| Outcome | Mean difference (95% CI) | P value | |
|---|---|---|---|
| CCI score, main pancreatic duct ≤3 mm (subgroup, n = 202) | −6.4 (−11.2 to −1.6) | P = 0.009 | |
| −15−10−505Difference (linear scale) |
Original publication
The Effect of Perioperative Dexamethasone on Postoperative Complications After Pancreaticoduodenectomy: A Multicenter Randomized Controlled Trial. Ann Surg. Published 22 February 2024. doi:10.
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