Perioperative medicine & outcomes
IMpact of PerioperAtive KeTamine on Enhanced Recovery After abdominal Surgery (IMPAKT enhanced recovery after surgery (ERAS)): a pragmatic randomised single-cluster trial
Primary result · Hospital LOSResult — go to the resultOdds ratio 1.21 95% CI 1.00–1.47Authors' conclusion
The addition of ketamine to a multimodal abdominal ERAS protocol provided no significant benefits and was associated with worse perioperative outcomes.
Study context
- Population
- Adults (≥18 yr) undergoing major abdominal surgery within an established ERAS protocol
- Participants
- 1,522 adults
- Comparison
- Ketamine vs saline placebo
- Primary endpoint
- Hospital LOS
Methodological detailspragmatic, double-blind, placebo-controlled, single-cluster
- Pragmatic
- Double-blind
- Placebo-controlled
- Single-cluster
Primary result
As reported in the abstract
Odds ratio
1.21
95% CI 1.00–1.47
Ketamine vs Placebo
OR 1.21 (95% CI 1.00–1.47)
Secondary outcomes
| Outcome | OR (95% CI) | |
|---|---|---|
| Opioid consumptionDid not decrease opioid consumption · covariate adjusted analyses | 0.85 (0.71–1.01) | |
| Meeting early discharge milestonesLower odds with ketamine | 0.68 (0.50–0.93) | |
| 0.512Odds ratio (log scale) |
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| ICU transferHigher odds with ketamine | 2.03 (1.14–3.63) | |
| Debilitating dizzinessHigher rates with ketamine | 6.05 (3.02–12.11) | |
| Debilitating hallucinationsHigher rates with ketamine | 2.69 (1.09–6.65) | |
| Other severe side-effectsHigher rates with ketamine | 1.94 (1.27–2.96) | |
| 0.050.21520Odds ratio (log scale) |
Rapid response activation
- Similar between groups
- OR 1.51; 95% CI 0.85-2.68
Ileus requiring nasogastric decompression
- Similar between groups
- OR 1.26; 95% CI 0.87-1.84
Original publication
IMpact of PerioperAtive KeTamine on Enhanced Recovery After abdominal Surgery (IMPAKT ERAS): a pragmatic randomised single-cluster trial. Br J Anaesth. Published 3 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →