The effects of anaesthesia and analgesia on short- and long-term outcomes following colorectal cancer surgery: Protocol for an international, pragmatic, cohort study (ENCORE∗)
Study context
- Population
- Adults (>18 years), ASA I–III, with colorectal cancer (CRC) stage I–III scheduled for elective CRC surgery (open or minimally invasive)>140 centres in >30 nations
- Planned comparison
- Anaesthetic and analgesic technique during CRC surgery
- Primary endpoint
- Short-term: time from day of surgery to return to intended oncologic therapy (RIOT) in patients expected to receive postoperative chemotherapy; long-term: incidence of recurrence and time to recurrence (TTR)
- Follow-up
- 3 years
Methodological detailsprotocol, international, multicentre, observational, Secondary outcomes: postoperative complications within 30 days, hospital LOS, DAH-30 and DAH-90, adverse events of oncological treatment; exploratory: practice variation
- Protocol
- International
- Multicentre
- Observational
- Secondary outcomes: postoperative complications within 30 days, hospital LOS, DAH-30 and DAH-90, adverse events of oncological treatment; exploratory: practice variation
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
The effects of anaesthesia and analgesia on short- and long-term outcomes following colorectal cancer surgery: Protocol for an international, pragmatic, cohort study (ENCORE∗). Eur J Anaesthesiol Intensive Care. Published 26 April 2024. doi:10.
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