The effects of intrathecal fentanyl on postoperative opioid utilization rates in elderly patients undergoing lower extremity orthopedic surgery: a randomized controlled trial
Authors' conclusion
In elderly patients undergoing lower extremity surgery, intrathecal fentanyl as an anesthetic adjuvant may correlate with reduced pain scores on PODS1-3 and decreased opioid requirements on POD3.High-dose fentanyl does not provide significant therapeutic advantages.
Study context
- Population
- Elderly patients undergoing lower extremity orthopedic surgeryratio 2:2:1
- Participants
- 180 patients
- Comparison
- Intrathecal bupivacaine plus fentanyl 25 µg or 50 µg vs bupivacaine alone
- Primary endpoint
- Rate of opioid use
Primary result
As reported in the abstract
Opioid analgesic use · POD3
P < 0.05
Secondary outcomes
NRS ≥ 4 · POD2 — BF1 and BF2 vs B
P < 0.05
NRS ≥ 4 · POD3 — BF1 and BF2 vs B
P < 0.05
| Outcome | P value |
|---|---|
| NRS ≥ 4 · POD1BF1 vs B · lower in BF1 | P < 0.05 |
Opioid analgesic use · POD1-2
- No significant difference among the groups
- P > 0.05
Analgesic drug use · POD1-3
- Similar among the three groups
- P > 0.05
Original publication
The effects of intrathecal fentanyl on postoperative opioid utilization rates in elderly patients undergoing lower extremity orthopedic surgery: a randomized controlled trial. Perioper Med (Lond). Published 19 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →