Hemodynamics, fluids & transfusion
The effects of respiratory rate and tidal volume on pulse pressure variation in healthy lungs–a generalized additive model approach may help overcome limitations
Authors' conclusion
Correcting PPV for VT could improve PPV's predictive utility. Low HR/RR has limited effect on GAM-derived PPV, indicating that the low HR/RR limitation is related to how PPV is calculated. We did not demonstrate any benefit of GAM-derived PPV in predicting fluid responsiveness.
Study context
- Population
- Patients scheduled for open abdominal surgery, ventilated with VT 4 to 10 ml kg-1 and RR 10 to 31 min-1 before a 250 ml fluid bolus50 received fluid bolus
- Participants
- 52 patients
- Exposure
- Classic PPV vs generalized additive model (GAM) PPV
- Outcome
- Effects of VT and RR on PPV and on PPV's ability to predict fluid responsiveness (stroke volume (SV) increase > 10%)
Main finding
As reported in the abstract
Fluid responsiveness prediction with PPV (AUC)
Prediction inconclusive for all ventilator settings; AUC point estimates
between 0.62 and 0.82
Fluid responders
10
Observational data: associations, not effects.
Original publication
The effects of respiratory rate and tidal volume on pulse pressure variation in healthy lungs–a generalized additive model approach may help overcome limitations. J Clin Monit Comput. Published 16 November 2023. doi:10.
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