The Fragility Index of randomized controlled trials in pediatric anesthesiology
Authors' conclusion
The FI of published trials in pediatric anesthesiology is similarly low as in other medical specialties. Larger trials with more events and P values ≤ 0.01 were associated with a higher FI.
Study context
- Population
- Pediatric anesthesiology randomized controlled trials (RCTs) comparing an intervention between two groups with a statistically significant P value (< 0.05) for a dichotomous outcome
- Outcome
- Fragility Index (FI): number of outcome events that would need to change to nonevents to render a significant P value nonsignificant (P ≥ 0.05)
Methodological detailsmeta-research study of Fragility Index, comprehensive systematic search, high-impact anesthesia, surgical and medical journals, last 25 years
- Meta-research study of Fragility Index
- Comprehensive systematic search
- High-impact anesthesia, surgical and medical journals
- Last 25 years
Pooled result
As reported in the abstract
Fragility Index
Median [IQR] Fragility Index (FI)
3
1–7
Further pooled results
Association of FI with trial characteristics
- Positive correlation with number of participants (rS)
- 0.41; P < 0.001
- Positive correlation with number of events (rS)
- 0.42; P < 0.001
- Negative correlation with P value (rPB)
- −0.36; P < 0.001
- Other measures of trial quality and impact or importance not strongly associated with FI
Original publication
The Fragility Index of randomized controlled trials in pediatric anesthesiology. Can J Anaesth. Published 8 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →