Sepsis & infection

The Frame of Survival for Sepsis: A Practical Systems Framework for Time-Sensitive Critical Illness in Low-Resource Settings

Crit Care MedPublished Consensus framework (SCCM task force) based on a targeted scoping review

Methodological detailsDelphi-style prioritization, structured consensus meeting ("Utstein-style" conference format), multidisciplinary task force
  • Delphi-style prioritization
  • Structured consensus meeting ("Utstein-style" conference format)
  • Multidisciplinary task force

Recommendations

As issued by the authors

  1. Triage and early recognition

  2. Timely antimicrobials

  3. Oxygen and basic supportive care

  4. Cautious fluid resuscitation with reassessment

  5. Source control and referral

  6. Diagnostics/microbiology where feasible

  7. Quality improvement (QI)

  8. Distinguish near-term, feasible changes from longer-term system investments

  9. Generate local evidence to guide quality indicators and resuscitation strategies in low-resource settings (LRS)

Original publication

The Frame of Survival for Sepsis: A Practical Systems Framework for Time-Sensitive Critical Illness in Low-Resource Settings. Crit Care Med. Published 20 March 2026. doi:10.1097/ccm.0000000000007093

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