ICU sedation, delirium & recovery
The Impact of Centrally Acting Drug Burden at Discharge on Long-Term Outcomes Among ICU Survivors
Authors' conclusion
Within our cohort of ICU survivors, we did not find a significant association of centrally acting drug burden measured by the DBI with long-term cognitive impairment, physical disability, or 90-day mortality.
Study context
- Population
- Adults with respiratory failure and/or shock discharged alive from the ICU478 cognitive, 490 physical data
- Participants
- 676 adults
- Comparison
- Association of centrally acting drug burden (drug burden index (DBI)) at hospital discharge with long-term outcomes
Methodological detailssingle-centre, tertiary academic medical center
- Single-centre
- Tertiary academic medical center
Primary result
As reported in the abstract
Discharge DBI and long-term outcomes
Discharge DBIEstimate (95% CI)P value
Long-term cognitive impairment
OR 1.25(0.89–1.76)
P = 0.20Katz ADL
OR 1.08(0.80–1.44)
P = 0.62FAQ
OR 1.15(0.89–1.49)
P = 0.2990-day mortality
HR 0.87(0.61–1.23)
P = 0.42Further findings
Median DBI during hospitalization
- Median DBI at admission
- 1.96
- Median DBI at ICU transfer
- 2.42
- Median DBI at hospital discharge
- 3.08
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The Impact of Centrally Acting Drug Burden at Discharge on Long-Term Outcomes Among ICU Survivors. Crit Care Med. Published 9 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →