Respiratory failure & ventilation
The Impact of Delayed Transition From Noninvasive to Invasive Mechanical Ventilation on Hospital Mortality in Immunocompromised Patients With Sepsis*
Main finding · Hospital mortalityResult — go to the resultAdjusted hazard ratio 1.006 95% CI 0.959–1.055Authors' conclusion
Prolonged NIV trial before delayed IMV transition is associated with higher mortality in immunocompromised sepsis patients ultimately intubated.
Study context
- Population
- Adult immunocompromised patients with sepsis requiring ventilation, 3530 hospitals across China, 2017–2019
- Participants
- 36,187 participants · 3,530 hospitals
- Exposure
- Initial noninvasive ventilation (NIV) vs initial invasive mechanical ventilation (IMV)
- Outcome
- Hospital mortality
Methodological detailsnational claims data, multicentre, weighted Cox models
- National claims data
- Multicentre
- Weighted Cox models
Main finding
As reported in the abstract
median 9-day follow-up
Adjusted hazard ratio
1.006
95% CI 0.959–1.055
NIV vs IMV
aHR 1.006 (95% CI 0.959–1.055)
- Immediate transition to IMV (≤ 1 d) vs initial IMV, HR
- 1.65
- Late transition to IMV (≥ 8 d) vs initial IMV, HR
- 2.51
Observational data: associations, not effects.
Further findings
| Outcome | HR |
|---|---|
| Hospital mortality by time to IMV transition among NIV patientsImmediate vs IMV initiation | 1.65 |
| Hospital mortality by time to IMV transition among NIV patientsLate vs IMV initiation | 2.51 |
Hospital mortality by time to IMV transition among NIV patients
- Longer time to IMV transition associated with stepwise increases in mortality; dose-response persisted across subgroups and sensitivity analyses
Original publication
The Impact of Delayed Transition From Noninvasive to Invasive Mechanical Ventilation on Hospital Mortality in Immunocompromised Patients With Sepsis*. Crit Care Med. Published 21 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →