Cardiac arrest & resuscitation
The impact of double sequential shock timing on outcomes during refractory out-of-hospital cardiac arrest
Authors' conclusion
Among patients in refractory VF a DSED interval of less than 75 ms was associated with improved rates of VF termination and ROSC. No association was noted between DSED interval and survival to hospital discharge or neurologic outcome.
Study context
- Population
- Adults (≥18 years) with OHCA in refractory VF who received ≥1 double sequential external defibrillation (DSED) shock, January 2015 to May 2022303 DSED shocks
- Participants
- 106 adults
- Exposure
- DSED interval categories vs <75 ms
- Outcome
- VF termination, return of spontaneous circulation (ROSC), survival to hospital discharge and favourable neurological status (MRS ≤ 2)
Main finding
As reported in the abstract
VF termination
Each group vs <75 msOdds ratio (95% CI)
75-125 ms
0.39(0.16–0.98)
125-500 ms
0.36(0.16–0.82)
>500 ms
0.27(0.11–0.63)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| ROSC>75 ms vs <75 ms | 0.37 (0.14–0.98) | |
| 0.10.31310Odds ratio (log scale) |
Survival to hospital discharge, neurologic outcome
- No association between DSED interval and survival to hospital discharge or neurologic outcome
Original publication
The impact of double sequential shock timing on outcomes during refractory out-of-hospital cardiac arrest. Resuscitation. Published 11 December 2023. doi:10.
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