Cardiac arrest & resuscitation
The impact of the AIRWAYS-2 randomised controlled trial on clinical practice in out-of-hospital cardiac arrest in England: A registry-based cohort study
Authors' conclusion
In England, the proportion of adult OHCA patients receiving tracheal intubation decreased between 2014 and 2020. This decrease accelerated following August 2018, which may be partly attributable to the AIRWAYS-2 trial results.
Study context
- Population
- Adult OHCA patients treated 2014–2020 by English emergency medical services submitting advanced airway data (English OHCA Outcomes registry)
- Participants
- 73,764 patients · 7 EMS systems
- Exposure
- Tracheal intubation use before vs after AIRWAYS-2 publication
- Outcome
- Association between publication of AIRWAYS-2 and use of tracheal intubation (segmented regression)
Methodological detailssegmented regression
- Segmented regression
Main finding
As reported in the abstract
Estimated percentage decrease in tracheal intubation use per quarter
Before AIRWAYS-2
−0.02
95% CI −0.02–-0.01 · % per quarter
After AIRWAYS-2
−2.01
95% CI −2.04–-1.99 · % per quarter
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted OR (95 % CI) | |
|---|---|---|
| Odds of tracheal intubation per quarter over 7-year period | 0.93 (0.93–0.94) | |
| 0.512Adjusted odds ratio (log scale) |
Proportion receiving tracheal intubation
%
- 2014
- 44
- 2020
- 14
Original publication
The impact of the AIRWAYS-2 randomised controlled trial on clinical practice in out-of-hospital cardiac arrest in England: A registry-based cohort study. Resuscitation. Published 11 September 2025. doi:10.
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