Respiratory failure & ventilation
The impact of timing of initiating invasive mechanical ventilation in COVID-19-related respiratory failure
Authors' conclusion
Initiation of IMV on each day after patients reach high FiO2 threshold was associated with higher inpatient mortality after adjusting for time-varying confounders. Remaining on high flow nasal cannula or non-invasive ventilation does not appear to be harmful compared to IMV.
Study context
- Population
- Patients with COVID-19-related acute respiratory failure reaching ≥80% FiO2 on HFNC or NIV, Kaiser Permanente Northern/Southern California's 36 medical centers
- Participants
- 5,758 patients
- Exposure
- Invasive mechanical ventilation (IMV) vs No IMV
- IMVn = 2,793
- No IMVn = 2,965reference
- Outcome
- In-hospital mortality
Methodological detailspropensity scores with overlap weighting, multicentre
- Propensity scores with overlap weighting
- Multicentre
Main finding
As reported in the abstract
Inpatient death (adjusted) · each day after T0 through day >10
- Adjusted RR higher for IMV vs no IMV on each day after reaching T0 through day >10 (RR>1)
- Propensity scores with overlap weighting
Observational data: associations, not effects.
Further findings
Unadjusted mortality
P < 0.0001
Original publication
The impact of timing of initiating invasive mechanical ventilation in COVID-19-related respiratory failure. J Crit Care. Published 8 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →