Cardiac arrest & resuscitation
The impact of vasopressor choice in patients with hypotension after cardiac arrest: a systematic review
Authors' conclusion
Existing evidence does not support the use of any specific vasopressor to treat hypotension following cardiac arrest and return of spontaneous circulation.
Study context
- Population
- Adults with hypotension after return of spontaneous circulation following cardiac arrest8 studies (1 RCT)
- Comparison
- Vasopressor choice after cardiac arrest
- Outcome
- Survival and survival with favourable neurologic function
Methodological detailsno meta-analysis (heterogeneity), GRADE certainty assessment
- No meta-analysis (heterogeneity)
- GRADE certainty assessment
Pooled result
As reported in the abstract
- Single RCT: no evidence of difference in outcomes between noradrenaline and adrenaline
- Other noradrenaline vs adrenaline studies inconsistent: some no difference, others suggested association of adrenaline with worse outcomes
- Risk of bias moderate or high; evidence certainty very low for all comparisons and outcomes
- Study heterogeneity precluded meta-analysis
Original publication
The impact of vasopressor choice in patients with hypotension after cardiac arrest: a systematic review. Resuscitation. Published 17 November 2025. doi:10.
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