Cardiac arrest & resuscitation
Postresuscitation oxygen reserve index-guided oxygen titration in out-of-hospital cardiac arrest survivors: A randomised controlled trial
Primary result · Normoxia indexResult — go to the resultDifference 0.019 95 % CI −0.056-0.095Authors' conclusion
Oxygen reserve index- combined with pulse oximetry-based prehospital oxygen titration did not significantly improve the normoxia index compared with standard oxygen titration based on pulse oximetry alone
Study context
- Population
- Patients with return of spontaneous circulation after cardiac arrest, during prehospital transport (FIO2 titrated to SpO2 94–98%)
- Participants
- 92 patients
- Comparison
- Intervention vs Control
- Primary endpoint
- Normoxia index (proportion of hyperoxia- and hypoxia-free time during prehospital intervention)
- Follow-up
- During prehospital intervention
Methodological detailsprospective, 1:1 randomisation
- Prospective
- 1:1 randomisation
Primary result
Normoxia index
Difference
0.019
95 % CI −0.056-0.095
By group
Control
0.828
mean
Intervention
0.847
mean
Intervention vs Control
difference 0.019 (95 % CI −0.056-0.095)
As reported in the abstract
Further findings
PaO2 at hospital admission · no difference
P = 0.86
Incidence of hypoxia or hyperoxia
- No significant differences between groups
Serum neuron-specific enolase · 48 h post-ROSC
- No difference after adjustment for known confounders
Original publication
Postresuscitation oxygen reserve index-guided oxygen titration in out-of-hospital cardiac arrest survivors: A randomised controlled trial. Resuscitation. Published 18 October 2023. doi:10.
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