Cardiac arrest & resuscitation
Sedation early after return of spontaneous circulation and during pre-hospital transport after out-of-hospital cardiac arrest: retrospective analysis of the AfterROSC1 & 2 database
Authors' conclusion
The decision of sedation started after ROSC and before ICU admission was associated with a good functional recovery on day 90.
Study context
- Population
- Post-cardiac arrest patients after OHCA with return of spontaneous circulation (ROSC)
- Participants
- 1,596 patients
- Exposure
- Sedation started vs not started during pre-hospital care after ROSC
- Sedatedn = 1,324
- Not sedatedn = 272reference
- Outcome
- Day-90 survival with favorable neurological outcome (modified Rankin scale 0-3)
- Follow-up
- Day 90
Methodological detailsAfterROSC1 and AfterROSC2 cohorts, multicentre
- AfterROSC1 and AfterROSC2 cohorts
- Multicentre
Main finding
As reported in the abstract
Favorable neurological outcome (modified Rankin scale 0-3)
Sedated vs Not sedatedAdjusted odds ratio (95% CI)P value
Adjusted for mCAHP score and center
2.19(1.31–3.65)
P = 0.003- Not significant after propensity score adjustment
- propensity score adjusted 1.40 (95% CI 0.70–2.09); P = 0.26
Observational data: associations, not effects.
Further findings
Disease severity (mCAHP score)
- mCAHP score higher in the group without pre-ICU sedation
- median: 90 [70-106] vs. 105 [90-116]
- P = 0.001
Original publication
Sedation early after return of spontaneous circulation and during pre-hospital transport after out-of-hospital cardiac arrest: retrospective analysis of the AfterROSC1 & 2 database. Resuscitation. Published 4 July 2026. doi:10.
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