The number of central nervous system-driven symptoms predicts subsequent chronic primary pain: evidence from UK Biobank
Main finding · Risk of future primary pain per number of CNS-driven symptomsResult — go to the resultHazard ratio 1.43 95% CI 1.34–1.52Authors' conclusion
In adults with no current self-reported pain, those with a greater number of CNS-driven symptoms at baseline were more likely to develop a primary pain condition.
Study context
- Population
- UK Biobank adults with no self-reported recent or chronic pain at baselineof 502,369 participants
- Participants
- 70,630 adults
- Exposure
- Number of central nervous system (CNS)-driven symptoms at baseline
- Outcome
- Incidence of primary pain conditions
Methodological detailsUK Biobank, linked primary care records, multivariable regression
- UK Biobank
- Linked primary care records
- Multivariable regression
Main finding
As reported in the abstract
Risk of future primary pain per number of CNS-driven symptoms · 7.4 (range 0.5-11.02) yr
Hazard ratio
1.43
95% CI 1.34–1.52
P < 0.001
Number of CNS-driven symptoms at baseline
HR 1.43 (95% CI 1.34–1.52); P < 0.001
Per number of CNS-driven symptoms, as printed
- Developed a primary pain condition
- 12.2%
Observational data: associations, not effects.
Further findings
Chronic and more severe nociplastic pain vs non-nociplastic pain at follow-up
- More CNS-driven symptoms at baseline associated with chronic and more severe nociplastic pain, but not non-nociplastic pain
Original publication
The number of central nervous system-driven symptoms predicts subsequent chronic primary pain: evidence from UK Biobank. Br J Anaesth. Published 27 January 2025. doi:10.
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