Chronic pain in multiple sites is associated with cardiovascular dysfunction: an observational UK Biobank cohort study
Main finding · Arterial stiffness indexResult — go to the resultβ 0.06 95% CI 0.04–0.08Authors' conclusion
A greater number of chronic pain sites is associated with increased arterial stiffness and poorer cardiac function, suggesting that widespread chronic pain is an important contributor to cardiovascular dysfunction.
Study context
- Population
- UK Biobank participants examined at baseline, first follow-up and two imaging visitsarterial stiffness analysis
- Participants
- 159,360 participants
- Exposure
- Number of chronic pain sites
- Outcome
- Arterial stiffness index
Methodological detailsUK Biobank, mixed-effect linear regression
- UK Biobank
- Mixed-effect linear regression
Main finding
As reported in the abstract
β
0.06
95% CI 0.04–0.08
Observational data: associations, not effects.
Further findings
| Outcome | β (95% CI) |
|---|---|
| LVEFn=23,899 | −0.17 (−0.27 to −0.07) |
Carotid intima-media thickness and cardiac index
- Number of chronic pain sites not associated with carotid intima-media thickness (n=30,628) or cardiac index (n=23,899)
Original publication
Chronic pain in multiple sites is associated with cardiovascular dysfunction: an observational UK Biobank cohort study. Br J Anaesth. Published 14 July 2024. doi:10.
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