Perioperative medicine & outcomes
The number of comorbidities as an important cofactor to ASA class in predicting postoperative outcome: An international multicentre cohort study
Authors' conclusion
These data quantify the high prevalence of multimorbidity in the surgical population and show that the number of comorbidities is predictive of negative postoperative outcomes, independent of ASA class.
Study context
- Population
- Patients of all ages undergoing any type of in-hospital surgery, followed up to 30 days postoperativelyenrolled
- Participants
- 1,421 patients
- Exposure
- Number of comorbidities across ASA classes
- Outcome
- Number of comorbidities across ASA classes
Methodological detailsinternational multicentre, subpopulation of the ClassIntra® validation study, eight centres
- International multicentre
- Subpopulation of the ClassIntra® validation study
- Eight centres
Main finding
As reported in the abstract
Number of comorbidities
ASA I
1.5
mean · 95% CI 1.1–1.9
ASA IV
10.5
mean · 95% CI 8.3–12.7
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Increase (95% CI) | |
|---|---|---|
| Comprehensive Complication Index (CCI®, 0–100) per each comorbidity, independent of ASA class · 30 daysIndependent of ASA class | 0.81 (0.40–1.23) | |
| −0.500.511.5Difference (linear scale) |
| Outcome | Geometric mean ratio (95% CI) | |
|---|---|---|
| Postoperative LOS per each comorbidity, independent of ASA classIndependent of ASA class | 1.03 (1.01–1.06) | |
| 0.512Geometric mean ratio (log scale) |
Original publication
The number of comorbidities as an important cofactor to ASA class in predicting postoperative outcome: An international multicentre cohort study. Acta Anaesthesiol Scand. Published 1 July 2024. doi:10.
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