Sepsis & infection

The Precision Resuscitation With Crystalloids in Sepsis (PRECISE) Trial: A Trial Protocol

JAMA Netw OpenPublished Randomised controlled trial protocol

Study context

Population
Patients with suspicion of group D sepsis in whom a clinician initiates a normal saline order in the emergency department (ED) or intensive care unit (ICU), 6 Emory Healthcare hospitals
Planned comparison
Intervention vs Usual care
Primary endpoint
Inpatient mortality
Follow-up
30 days
Methodological detailsparallel-group, multihospital, single-blind, pragmatic, Planned ITT analysis
  • Parallel-group
  • Multihospital
  • Single-blind
  • Pragmatic
  • Planned ITT analysis

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

The Precision Resuscitation With Crystalloids in Sepsis (PRECISE) Trial: A Trial Protocol. JAMA Netw Open. Published 3 September 2024. doi:10.1001/jamanetworkopen.2024.34197

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