Neuroanesthesia & neurocritical care
The prescribing patterns and effectiveness of sedatives and analgesics for severe traumatic brain injury patients in Taiwan
Study context
- Population
- Severe traumatic brain injury (TBI) patients intubated during intensive care unit (ICU) hospitalization, Taiwan National Health Insurance Research Database, 2012–2019
- Participants
- 6,030 patients
- Exposure
- No prescription, sedation only or opioids only vs sedatives with opioids
- Outcome
- All-cause mortality
- Follow-up
- 30 days
Methodological detailsnational claims database, inverse probability of treatment weighting
- National claims database
- Inverse probability of treatment weighting
Main finding
As reported in the abstract
Each group vs sedatives with opioidsHazard ratio (95 % CI)P value
No-prescription
2.73(2.60–2.86)
P < 0.0001Sedation-only
1.58(1.50–1.66)
P < 0.0001Opioids-only
1.49(1.42–1.57)
P < 0.0001Observational data: associations, not effects.
Further findings
Prescribing pattern
- Midazolam combined with opioids the most common regimen
14-day mortality and 30-day mortality excluding deaths within 3 days (sensitivity analyses)
- Sensitivity analyses confirmed consistent trends
Original publication
The prescribing patterns and effectiveness of sedatives and analgesics for severe traumatic brain injury patients in Taiwan. J Crit Care. Published 25 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →