Neuroanesthesia & neurocritical care
Towards autoregulation-oriented management after traumatic brain injury: increasing the reliability and stability of the CPPopt algorithm
Authors' conclusion
The CPPopt calculation algorithm was fine-tuned and adapted for prospective use with acceptable lower yield, improved stability and maintained prognostic power.
Study context
- Population
- TBI patients in the Collaborative European Neuro Trauma Effectiveness Research in TBI (CENTER-TBI) high-resolution ICU cohort
- Exposure
- New vs previous CPPopt algorithm
- Outcome
- Stability and yield of the CPPopt algorithm
Methodological detailsalgorithm development and validation, multicentre
- Algorithm development and validation
- Multicentre
Main finding
As reported in the abstract
Yield and stability of CPPopt
P < 0.001
- Higher stability with new algorithm vs previous
- P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | New algorithm |
|---|---|
| Mortality prediction at 6 months by CPPopt deviation | |
| AUC | 0.69 (95% CI 0.59-0.78), p < 0.001 |
Mortality prediction at 6 months by CPPopt deviation
- Comparable with the previous algorithm
Original publication
Towards autoregulation-oriented management after traumatic brain injury: increasing the reliability and stability of the CPPopt algorithm. J Clin Monit Comput. Published 29 April 2023. doi:10.
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