Neuroanesthesia & neurocritical care
Optimal cerebrovascular reactivity thresholds for the determination of individualized intracranial pressure thresholds in traumatic brain injury: a CAnadian High-Resolution TBI (CAHR-TBI) cohort study
Authors' conclusion
With consideration of yield data, ability to predict outcome, and association with cerebral physiologic insult burden, a threshold of + 0.05 was identified for PRx. No optimal threshold could be identified for PAx or RAC.
Study context
- Population
- Patients with TBI, CAnadian High-Resolution TBI (CAHR-TBI) Research Collaborative
- Participants
- 365 patient data sets
- Exposure
- Cerebrovascular reactivity (CVR) indices at thresholds from - 1 to + 1 for individualized ICP (iICP) derivation
- Outcome
- CVR threshold best suited for iICP derivation (largest Chi-square for 6-month outcome prediction; association with cerebral physiologic insult burden)
- Follow-up
- 6 months
Methodological detailsmulticentre registry
- Multicentre registry
Main finding
As reported in the abstract
Optimal CVR threshold for iICP derivation
Optimal threshold identified for PRx
+ 0.05
Observational data: associations, not effects.
Original publication
Optimal cerebrovascular reactivity thresholds for the determination of individualized intracranial pressure thresholds in traumatic brain injury: a CAHR-TBI cohort study. Crit Care. Published 6 October 2025. doi:10.
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