Neuroanesthesia & neurocritical care
Prognostic value of near-infrared spectroscopy regional oxygen saturation and cerebrovascular reactivity index in acute traumatic neural injury: a CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Cohort Study
Authors' conclusion
In this multi-institutional cohort study, raw rSO2was found to contain no significant prognostic information. However, rSO2-based indices of CVR, COx and COx_a, were found to have a uniform grand mean threshold of 0.2 and exposure-based threshold of - 0.05, above which clinical outcomes markedly worsened.
Study context
- Population
- Traumatic brain injury (TBI) patients treated in four adult intensive care units (ICUs)
- Participants
- 129 patients · 4 adult ICUs
- Outcome
- Threshold values of rSO2 and rSO2-based cerebrovascular reactivity (CVR) (COx, COx_a) at which outcomes (survival, favorable outcome) worsened
Methodological detailsmulti-institutional
- Multi-institutional
Main finding
As reported in the abstract
Prognostic thresholds of rSO2, COx and COx_a
COx and COx_a: optimal grand mean threshold for survival and favorable outcomes
0.2
COx and COx_a: percent time above threshold with best discriminative value
- 0.05
Observational data: associations, not effects.
Original publication
Prognostic value of near-infrared spectroscopy regional oxygen saturation and cerebrovascular reactivity index in acute traumatic neural injury: a CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Cohort Study. Crit Care. Published 14 March 2024. doi:10.
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