Neuroanesthesia & neurocritical care
Cerebral physiologic insult burden in acute traumatic neural injury: a Canadian High Resolution-TBI (Canadian High-Resolution TBI (CAHR-TBI)) descriptive analysis
Authors' conclusion
Mean ICP, CPP and, cerebrovascular reactivity values demonstrate statistically significant associations with global cerebral physiologic insult burden; however, it is uncertain whether measures of oxygen delivery provide any significant insight into such insult burden.
Study context
- Population
- Patients with moderate-to-severe TBI, CAHR-TBI Research Collaborative
- Participants
- 369 complete datasets
- Comparison
- Low vs intermediate vs high mean values of cerebral physiologic metrics
- Outcome
- Associations between deranged cerebral physiology (ICP, CPP, cerebrovascular reactivity, PbtO2, rSO2) and cerebral physiologic insult burden
Methodological detailsCAHR-TBI Research Collaborative data
- CAHR-TBI Research Collaborative data
Main finding
As reported in the abstract
Cerebral physiologic insult burden
- Elevated intracranial pressure (ICP) associated with more time with cerebral perfusion pressure (CPP) < 60 mmHg and with impaired cerebrovascular reactivity
- Low CPP associated with more time with ICP > 20 or 22 mmHg and with impaired cerebrovascular reactivity
- Elevated cerebrovascular reactivity indices associated with more time with CPP < 60 mmHg and ICP > 20 or 22 mmHg
- Low PbtO2 significantly associated only with more time with CPP < 60 mmHg
- Low rSO2 not significantly associated with any measure of insult burden
- Jonckheere-Terpstra testing
Original publication
Cerebral physiologic insult burden in acute traumatic neural injury: a Canadian High Resolution-TBI (CAHR-TBI) descriptive analysis. Crit Care. Published 4 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →