Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial
Primary resultResult — go to the resultMedian absolute difference - 0.0 days 95% CI - 3.3 to 3.3Authors' conclusion
In a population of intensive care unit adults with acute pancreatitis and low requirement for intubation, this first multicenter randomized trial did not show the hypothesized benefit of epidural analgesia in addition to usual care.
Study context
- Population
- Adult ICU patients with a clinical diagnosis of acute pancreatitis135 in ITT analysis
- Participants
- 148 patients
- Comparison
- Thoracic epidural analgesia plus usual care vs usual care alone
- Interventionn = 65
- Controln = 70reference
- Primary endpoint
- Ventilator-free days from randomisation until day 30
- Follow-up
- Day 30
Methodological detailsmulticentre, open-label, Enrolment June 2014 to January 2019
- Multicentre
- Open-label
- Enrolment June 2014 to January 2019
Primary result
As reported in the abstract
Median absolute difference
- 0.0 days
95% CI - 3.3 to 3.3
P = 0.59
By group
Safety
- Epidural analgesia significantly associated with longer duration of invasive ventilation, median [IQR] (epidural analgesia vs control)
- 14 days [5-28] versus 6 days [2-13]
- p = 0.02
Original publication
Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial. Crit Care. Published 31 May 2023. doi:10.
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