Thrombolysis before venoarterial ECMO for high-risk pulmonary embolism: a retrospective cohort study
Authors' conclusion
Ninety-day survival and bleeding events rates did not differ in patients treated with VA-ECMO after systemic thrombolysis compared to those who were not.
Study context
- Population
- High-risk pulmonary embolism (PE) patients placed on venoarterial extracorporeal membrane oxygenation (VA-ECMO), three ICUs at Sorbonne University, June 2012–June 2023
- Participants
- 72 patients
- Exposure
- T + vs T-
- T +n = 31
- T-n = 41reference
- Outcome
- ECMO-related complications and mortality
- Follow-up
- 90 days
Methodological detailsmulticentre (three ICUs)
- Multicentre (three ICUs)
Main finding
As reported in the abstract
Survival
P = 0.31
Observational data: associations, not effects.
Further findings
Pre-ECMO cardiac arrest
P = 0.02
Long-term follow-up of hospital discharge survivors · median 69 (52-95) months
- Patients attending follow-up
- 25 over 28
- Chronic thromboembolic pulmonary hypertension
- 0
- Long-term quality of life acceptable
Safety
| Outcome | P value |
|---|---|
| Severe hemorrhagesNo difference | P = 1 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Thrombolysis before venoarterial ECMO for high-risk pulmonary embolism: a retrospective cohort study. Intensive Care Med. Published 24 June 2024. doi:10.
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