Pediatric anesthesia & critical care
Thrombotic Complications of Low‐Dose Versus High‐Dose Four‐Factor Prothrombin Complex Concentrate for Massive Bleeding in Pediatric Cardiovascular Surgery
Authors' conclusion
High-dose 4F-PCC was not associated with increased thrombotic complications.
Study context
- Population
- Pediatric patients who received 4F-PCC for massive bleeding during cardiovascular surgery, January 2018–April 2024of 1296 operated
- Participants
- 104 patients
- Exposure
- High-dose vs low-dose four-factor PCC
- Outcome
- Thrombotic complications
- Follow-up
- Within 15 days after use
Main finding
As reported in the abstract
within 15 days
P = 0.698
- Thrombotic complications overall
- 6.73%
Observational data: associations, not effects.
Further findings
Reintervention
Cramér's V 0.118 · P = 0.015
| Outcome | Cohen's d | P value |
|---|---|---|
| CPB timeShorter with high dose | 0.537 | P = 0.007 |
Original publication
Thrombotic Complications of Low‐Dose Versus High‐Dose Four‐Factor Prothrombin Complex Concentrate for Massive Bleeding in Pediatric Cardiovascular Surgery. Paediatr Anaesth. Published 28 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →