Pediatric anesthesia & critical care
Retrospective Comparison of Recombinant Activated Factor VII Versus 4-Factor Prothrombin Complex Concentrate in Cardiac Surgical Patients
Authors' conclusion
This retrospective study suggested that the administration of rFVIIa was associated with a higher risk of thrombotic complications when compared to 4F-PCC, without benefits in terms of bleeding and transfusions.
Study context
- Population
- Pediatric congenital cardiac surgical patients at a tertiary academic hospital
- Participants
- 89 vs 55
- Exposure
- rFVIIa vs 4F-PCC
- rFVIIan = 89
- 4F-PCCn = 55reference
- Outcome
- Thrombotic complications
Methodological detailssingle-centre, propensity-matched sensitivity analysis
- Single-centre
- Propensity-matched sensitivity analysis
Main finding
As reported in the abstract
Adjusted p = 0.023
Observational data: associations, not effects.
Further findings
| Outcome | 4F-PCC | rFVIIa | P value |
|---|---|---|---|
| Thrombosis, propensity-matched sensitivity analysisPropensity matching | 10% · n = 38 | 31% · n = 39 | P = 0.036 |
Chest tube output (days 1 and 2) and blood product transfusion
- No difference between groups
Thrombosis, propensity-matched sensitivity analysis
- No difference in bleeding or transfusion
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Retrospective Comparison of Recombinant Activated Factor VII Versus 4-Factor Prothrombin Complex Concentrate in Cardiac Surgical Patients. J Cardiothorac Vasc Anesth. Published 30 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →