Thrombotic Outcomes Associated With Factor Eight Inhibitor Bypassing Activity Use in Neonatal and Infant Cardiac Surgery Including the Norwood Procedure: A Propensity Score‒Matched Analysis
Authors' conclusion
This study found that FEIBA use was not associated with a statistically significant increase in postoperative thrombosis in neonates and infants after cardiac surgery. Though patients undergoing the Norwood procedure had a 2-fold (nonsignificant) increase in catheter-associated thrombosis, we found no increase in the rate of shunt thrombosis or intervention.
Study context
- Population
- Neonates and infants (<1 year) undergoing cardiac surgery with cardiopulmonary bypass (CPB), including the Norwood procedure; tertiary pediatric cardiac surgery center
- Participants
- 198 neonates · 4 matched cohorts
- Exposure
- Factor Eight Inhibitor Bypassing Activity (FEIBA) exposure vs no FEIBA exposure
- Outcome
- Postoperative thrombosis
- Follow-up
- 7 and 30 days
Methodological detailssingle-centre, propensity score-matched
- Single-centre
- Propensity score-matched
Main finding
As reported in the abstract
Postoperative thrombosis, all cohorts
- FEIBA exposure not associated with a statistically significant increase in the odds of thrombosis at 7 or 30 days in any cohort
- Propensity score-matched
Observational data: associations, not effects.
Further findings
| Outcome | FEIBA | No FEIBA | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Thrombosis, Norwood neonates (subgroup) · 7 days | 17.4% | 8.7% | 2.18 (0.37–17.28) | P = 0.405 | |
| Thrombosis, Norwood neonates (subgroup) · 30 days | 26.1% | 13.0% | 2.22 (0.48–12.13) | P = 0.319 | |
| Shunt intervention before stage II palliation, Norwood neonates (subgroup) | 0.20 (0.04–0.88) | P = 0.047 | |||
| 0.050.21520Odds ratio (log scale) |
Original publication
Thrombotic Outcomes Associated With Factor Eight Inhibitor Bypassing Activity Use in Neonatal and Infant Cardiac Surgery Including the Norwood Procedure: A Propensity Score‒Matched Analysis. J Cardiothorac Vasc Anesth. Published 30 May 2026. doi:10.
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