Cardiac arrest & resuscitation
Time-dependent association of grey-white ratio on early brain computed tomography (CT) predicting outcomes after cardiac arrest at hospital discharge
Authors' conclusion
The sensitivity and FPR of early GWR predicting in-hospital mortality and DNC after resuscitation from cardiac arrest varies over the initial post-arrest period.
Study context
- Population
- Patients resuscitated from cardiac arrest, unresponsive to verbal commands, with brain CT within 24 hours of arrest (excluding primary traumatic or neurological etiology), January 2010–December 2023
- Participants
- 2,204 patients
- Exposure
- GWR on brain CT at different times from arrest to CT, dichotomized at <1.10 and <1.20
- Outcome
- Sensitivity and false positive rate of GWR predicting in-hospital mortality and death by neurologic criteria (DNC)
- Follow-up
- First 24 hours post-arrest
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Prediction of in-hospital mortality
Sensitivity of GWR <1.10 and GWR <1.20 increased over the first four hours post-arrest, reaching a maximum after five hours
25%
False positive rates at all time points
<5%
Observational data: associations, not effects.
Further findings
In-hospital mortality and death by neurologic criteria (DNC) (overall)
- Died in hospital
- 1651 (75%)
- Progressed to DNC
- 248 (11%)
Prediction of DNC
- Similar temporal trends as for in-hospital mortality, although absolute values of sensitivity and false positive rate (FPR) varied
Original publication
Time-dependent association of grey-white ratio on early brain CT predicting outcomes after cardiac arrest at hospital discharge. Resuscitation. Published 26 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →