Time-Dependent Effects of Inotropic Exposure During Venoarterial Extracorporeal Membrane Oxygenation Support on the Probability of Extracorporeal Membrane Oxygenation Weaning Failure
Main finding · ECMO weaning failureResult — go to the resultHazard ratio 1.04 95% CI 1.00–1.07Authors' conclusion
Higher cumulative inotropic exposure was associated with an increased risk for ECMO weaning failure.
Study context
- Population
- Adults with severe cardiogenic shock (CS) receiving VA ECMO, 6 hospitals in the Netherlands, 2018–2024
- Participants
- 440 adults
- Exposure
- Higher vs lower cumulative inotropic exposure during VA ECMO
- Outcome
- ECMO weaning failure
- Follow-up
- Up to 30 days
Methodological detailsmulticentre, joint modeling
- Multicentre
- Joint modeling
Main finding
As reported in the abstract
Hazard ratio
1.04
95% CI 1.00–1.07
Higher vs lower cumulative inotropic exposure (AUC of standardized inotropic score per day) during VA ECMO
HR 1.04 (95% CI 1.00–1.07)
- Patients developing ECMO weaning failure
- 235 (53.4%)
Observational data: associations, not effects.
Further findings
30-day mortality · up to 30 days
| HR (95% CI) | ||
|---|---|---|
| Higher cumulative inotropic exposureAdjusted joint model | 1.04 (1.01–1.08) | |
| 0.512Hazard ratio (log scale) |
Protracted lactate clearance
| HR (95% CI) | ||
|---|---|---|
| Higher cumulative inotropic exposureAdjusted joint model | 0.96 (0.92–0.99) | |
| 0.512Hazard ratio (log scale) |
Inotropic support after VA ECMO initiation
- Remained largely unchanged in the days following VA ECMO initiation
Safety
Arrhythmias
| HR (95% CI) | ||
|---|---|---|
| Higher cumulative inotropic exposureAdjusted joint model | 1.05 (1.01–1.08) | |
| 0.512Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Time-Dependent Effects of Inotropic Exposure During Venoarterial Extracorporeal Membrane Oxygenation Support on the Probability of Extracorporeal Membrane Oxygenation Weaning Failure. Crit Care Med. Published 25 September 2026. doi:10.
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