Cardiac arrest & resuscitation
Time to return of spontaneous circulation and long-term outcomes in bystander-witnessed out-of-hospital cardiac arrest survivors
Authors' conclusion
In bystander-witnessed 30-day OHCA survivors, prolonged resuscitation does not preclude recovery, time-to-ROSC was associated with anoxic brain damage but not nursing home admission, return-to-work, or long-term survival.
Study context
- Population
- Adults with bystander-witnessed Out-of-hospital cardiac arrest (OHCA) (2016–2023) surviving ≥30 days, without prior anoxic brain damage or nursing home admissionpatients included, 78% male, median age 65, median time-to-ROSC 14 min · A 875 · B 869 · C 839
- Participants
- 2,583 adults
- Exposure
- Time from emergency call to return of spontaneous circulation (time-to-ROSC) groups B and C versus A
- An = 875reference
- Bn = 869
- Cn = 839
- Outcome
- Anoxic brain damage
- Follow-up
- 11-month
Methodological detailsDanish Cardiac Arrest Registry, time-to-event and multivariable regression analyses
- Danish Cardiac Arrest Registry
- Time-to-event and multivariable regression analyses
Main finding
As reported in the abstract
Each group vs AHazard ratio (95% CI)
B
5.58(1.58–19.64)
C
9.98(2.93–33.96)
Observational data: associations, not effects.
Further findings
Nursing home admission · 11-month
- Nursing home admission: unadjusted p = 0.04
- Nursing home admission: adjustments attenuated the association (p = 0.3)
Long-term survival · 5-year
- 5-year Kaplan-Meier estimate, overall
- 79%; 95% CI 77-81%
- Similar across time-to-ROSC groups
- p = 0.80
- Adjusted p = 0.99
Return-to-work, among employed patients (n = 177, 168, 179) · 5-year
- 5-year cumulative incidence among employed patients, overall
- 60%; 95% CI 56-65%
- Similar across time-to-ROSC groups
- p = 0.31
- Adjusted p = 0.29
Original publication
Time to return of spontaneous circulation and long-term outcomes in bystander-witnessed out-of-hospital cardiac arrest survivors. Resuscitation. Published 6 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →