ICU sedation, delirium & recovery
Time-Varying Associations Between Selected Clinical Indicators And In-Hospital Mortality During The Early Period Of Critical Care
Authors' conclusion
The strength of association between selected clinical variables and in-hospital mortality varied with time during early periods of ICU care.
Study context
- Population
- Adults (aged 18 to 102) treated in three intensive care units (ICUs) at a single academic medical center, 2018 to 2023
- Participants
- 17,769 adults · 19,439 ICU encounters
- Outcome
- In-hospital mortality (association with nine selected clinical variables across sequential time intervals of early ICU care)
- Follow-up
- First 20 consecutive time intervals
Methodological detailssingle-centre, time-interval multivariable logistic regression
- Single-centre
- Time-interval multivariable logistic regression
Main finding
As reported in the abstract
Odds ratios for in-hospital death by clinical variable across time intervals
Age, sex, platelet count, hemoglobin, transfusion: OR range, small variations across periods of care
1.01 to 1.35
Ventilator use, dialysis, pressors, bilirubin: OR range, varied more widely
1.43 to 4.75
Observational data: associations, not effects.
Further findings
Duration of analysed time intervals of care
- Mean duration (± SD), minutes
- 512 ±215
- Median duration (IQR 326-720), minutes
- 574
Proportion of in-hospital mortality occurring during the first 20 time intervals
- One third of in-hospital mortality among ICU patients
Original publication
Time-Varying Associations Between Selected Clinical Indicators And In-Hospital Mortality During The Early Period Of Critical Care. Anesth Analg. Published 16 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →