Timing Is Everything: Early Initiation of Venous Thromboembolism (VTE) Prophylaxis Following Major Trauma Is Effective and Safe
Main finding · VTEResult — go to the resultOdds ratio 0.58 95% CI 0.44–0.78Authors' conclusion
Initiating VTE prophylaxis within the first 24 hours after admission resulted in a 42% reduction of the risk of VTE without increased risk of bleeding
Study context
- Population
- Major trauma patients at risk for VTE
- Participants
- 3,369 vs 3,200
- Exposure
- Pharmacologic VTE prophylaxis started ≤24 h vs >24 h after admission
- EARLYn = 3,369
- LATEn = 3,200reference
- Outcome
- VTE
Methodological detailsgeneralized linear mixed model
- Generalized linear mixed model
Main finding
As reported in the abstract
Odds ratio
0.58
95% CI 0.44–0.78
P < 0.001
By group
EARLY vs LATE
OR 0.58 (95% CI 0.44–0.78); P < 0.001
Observational data: associations, not effects.
Further findings
VTE type among 345 patients with VTE · events/value = DVT alone
DVT alone EARLY 61 (65%) · LATE 181 (72%)
PE alone EARLY 22 (23%) · LATE 46 (18%)
DVT and PE EARLY 11 (12%) · LATE 24 (10%)
Mortality
P < 0.001
Safety
Increased or new intracranial hemorrhage after prophylaxis initiation
P = 0.009
Original publication
Timing Is Everything: Early Initiation of VTE Prophylaxis Following Major Trauma Is Effective and Safe. Ann Surg. Published 10 June 2025. doi:10.
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