Timing of Antibiotic Prophylaxis Prior to Abdominal Surgery Has No Impact on Infectious Complications: A Retrospective Matched Cohort Study
Authors' conclusion
PAP timing did not significantly affect in-hospital infectious complications following elective open abdominal surgery, and antimicrobial resistance did not confound this association.
Study context
- Population
- Patients undergoing open elective CDC II–III abdominal surgeries at a high-volume university hospital in Germany (2013–2018)matched cohort
- Participants
- 1,193 patients
- Exposure
- Perioperative antibiotic prophylaxis (PAP) on time vs not on time
- OTn = 443
- NTn = 750reference
- Outcome
- Incidence of in-hospital postoperative infectious complications
Methodological detailssingle-center, propensity score matching, Despite matching, differences in ASA grade, malignancy, procedure type, and duration remained
- Single-center
- Propensity score matching
- Despite matching, differences in ASA grade, malignancy, procedure type, and duration remained
Main finding
As reported in the abstract
Infectious complications, all patients
196 patients
16.4%; 229 events
Observational data: associations, not effects.
Further findings
Infectious complications, procedures >200 minutes (subgroup)
- Fewer complications with OT
Organisms resistant to PAP
- Infection-causing organisms resistant to PAP
- 41.9%
- Antimicrobial resistance did not alter observed associations
Predictors of surgical site infections (multivariable analysis)
- Procedure duration an independent predictor
Original publication
Timing of Antibiotic Prophylaxis Prior to Abdominal Surgery Has No Impact on Infectious Complications: A Retrospective Matched Cohort Study. Ann Surg. Published 7 July 2025. doi:10.
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