Neuroanesthesia & neurocritical care
Visualizing the burden of brain tissue hypoxia and metabolic dysfunction assessed by multimodal neuromonitoring in subarachnoid hemorrhage patients: the TITAN study
Authors' conclusion
In this study, low PbtO2 and metabolic insults were more prevalent among SAH patients with unfavorable long-term neurological outcome at 6 months.
Study context
- Population
- Subarachnoid hemorrhage (SAH) patients admitted to 5 neurocritical care units requiring invasive multimodal neuromonitoring
- Participants
- 232 patients
- Outcome
- Neurological outcome (Glasgow Outcome Scale (GOS)) in relation to episodes of low PbtO2 and elevated lactate pyruvate ratio (LPR, cerebral microdialysis)
- Follow-up
- 6 months
Methodological detailsmulticentre, Median 117 (IQR 77-154) h of monitoring per patient
- Multicentre
- Median 117 (IQR 77-154) h of monitoring per patient
Main finding
As reported in the abstract
Unfavorable neurological outcome (GOS 1-3) at 6 months
- Combined episodes of low PbtO2 and elevated LPR prevalent in patients with unfavorable neurological outcome
- Association less evident with isolated low PbtO2 or isolated elevated LPR
- Cumulative PbtO2/LPR burden independently associated with unfavorable neurological outcome (multivariate model)
Observational data: associations, not effects.
Original publication
Visualizing the burden of brain tissue hypoxia and metabolic dysfunction assessed by multimodal neuromonitoring in subarachnoid hemorrhage patients: the TITAN study. Intensive Care Med. Published 22 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →