Pediatric anesthesia & critical care
Total Intravenous Versus Volatile Anesthesia in Pediatric Cardiac Surgery: Inflammatory Response and Early Recovery Profiles
Authors' conclusion
Interleukin-6 responses, the primary outcome, were comparable between groups. However, TIVA was associated with higher early MMSE scores and shorter ventilation duration, suggesting potential neuroprotective benefits.
Study context
- Population
- Children aged 1 to 12 years undergoing elective open heart surgery requiring CPB, tertiary pediatric cardiac surgery centre
- Participants
- 50 children
- Comparison
- Propofol-based total intravenous anesthesia (TIVA) vs sevoflurane-based volatile anaesthesia
- Primary endpoint
- Interleukin-6 concentration
- Follow-up
- Baseline, 6 hours, and 24 hours postoperatively
Methodological detailsprospective, single-centre
- Prospective
- Single-centre
Primary result
As reported in the abstract
- Interleukin-6 increased significantly in both groups; no difference between groups at any time point
Secondary outcomes
Duration of mechanical ventilation · shorter in the TIVA group
P = 0.045
| Outcome | TIVA | Volatile | P value |
|---|---|---|---|
| Pediatric-adapted MMSE score (children aged 4 years and older) · 24 hours post extubationSignificantly higher in the TIVA group | mean 23.7 ± 2.1 | mean 15.1 ± 3.0 | P < 0.01 |
| Pediatric-adapted MMSE score (children aged 4 years and older) · 48 hours | 27.2 ± 1.4 | 23.6 ± 2.8 | P < 0.05 |
- Pediatric-adapted Mini-Mental State Examination (MMSE) score (children aged 4 years and older): assessed in 34 children
- Pediatric-adapted MMSE score (children aged 4 years and older): assessed in 34 children
Original publication
Total Intravenous Versus Volatile Anesthesia in Pediatric Cardiac Surgery: Inflammatory Response and Early Recovery Profiles. J Cardiothorac Vasc Anesth. Published 9 October 2025. doi:10.
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