Pediatric anesthesia & critical care
The Anti-Inflammatory and Antioxidant Effects of Propofol and Sevoflurane in Children With Cyanotic Congenital Heart Disease
Authors' conclusion
The results showed that propofol provided a greater antioxidant effect and reduced SIRS postoperatively more than sevoflurane in children with CCHD undergoing cardiac surgery.
Study context
- Population
- Children aged 1–10 years with cyanotic congenital heart disease (CCHD) undergoing elective cardiac surgery with CPB
- Comparison
- Propofol vs sevoflurane GA
Methodological detailsprospective, double-blind, single-centre
- Prospective
- Double-blind
- Single-centre
Primary result
As reported in the abstract
Anti-inflammatory and antioxidant effects (systemic inflammatory response syndrome (SIRS), IL-6, TNF-α, total antioxidant status (TAS), TOS)
- No significant differences between groups in mean TNF-α and IL-6 levels at any time
- Group S vs group P: P = 0.020
- Group S vs group P: P = 0.036
- Group S vs group P: P = 0.004
- Group S vs group P: P = 0.008
- Group P vs group S: P = 0.036
- Group P vs group S: P = 0.041
Original publication
The Anti-Inflammatory and Antioxidant Effects of Propofol and Sevoflurane in Children With Cyanotic Congenital Heart Disease. J Cardiothorac Vasc Anesth. Published 30 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →