Tracheal Narrowing and Its Impact on Anesthesia Care in Patients With Morquio A (Mucopolysaccharidosis Type IVA): An Observational Study
Authors' conclusion
Clinically significant tracheal narrowing was present in patients with Morquio A, and the degree of such narrowing likely contributed to the difficulty with airway management during their anesthetic care. Tracheal narrowing worsens with age, but the progression appears to slow down after 20 years of age.
Study context
- Population
- Patients with Morquio A (mucopolysaccharidosis IVA) with airway evaluated by CT angiography and an anesthetic within a year44 with CT angiography and anesthetic
- Participants
- 92 patients
- Outcome
- Degree of tracheal narrowing and airway management difficulties during anesthesia care
Methodological detailsretrospective data collection
- Retrospective data collection
Main finding
As reported in the abstract
Tracheal narrowing
Correlation of age with tracheal narrowing (Spearman rs; 95% CI 0.138-0.691; P = .005); older patients greater narrowing
0.415
Observational data: associations, not effects.
Further findings
Spirometry (FEF25%-75%) vs tracheal narrowing
- Inverse correlation of FEF25%-75% with tracheal narrowing
- −0.467 (Spearman rs; 95% CI −0.877 to −0.057; P = .007)
Original publication
Tracheal Narrowing and Its Impact on Anesthesia Care in Patients With Morquio A (Mucopolysaccharidosis Type IVA): An Observational Study. Anesth Analg. Published 9 May 2023. doi:10.
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