Cardiac arrest & resuscitation

Training in Basic Life Support and Bystander-Performed Cardiopulmonary Resuscitation and Survival in Out-of-Hospital Cardiac Arrests in Denmark, 2005 to 2019

JAMA Netw OpenPublished Registry-based cohort study

Main finding · Annual 30-day survival per 5% increase in BLS course participation rateResult — go to the resultOR for 30-day survival 1.14 95% CI 1.10–1.18

Authors' conclusion

In this cohort study of Danish BLS course participation and survival, a positive association was found between annual rate of mass education in BLS and 30-day survival from OHCA. The association of BLS course participation rate on 30-day survival was mediated by the bystander CPR rate; approximately 60% of the association of BLS course participation rate on 30-day survival was based on factors other than increased CPR rates.

Study context

Population
All Out-of-hospital Cardiac Arrest (OHCA) incidents in the Danish Cardiac Arrest Register, 2005–2019
Participants
51,057 OHCA incidents
Exposure
Annual basic life support (BLS) course participation rate
Outcome
30-day survival after OHCA
Follow-up
30 days
Methodological detailsnationwide registry, logistic regression, bayesian mediation analysis
  • Nationwide registry
  • Logistic regression
  • Bayesian mediation analysis

Main finding

As reported in the abstract

Annual 30-day survival per 5% increase in BLS course participation rate

OR for 30-day survival

1.14

95% CI 1.10–1.18

P < 0.001

BLS course participation rate +5%
OR for 30-day survival 1.14 (95% CI 1.10–1.18); P < 0.001

Per 5% increase in BLS course participation, as printed

Observational data: associations, not effects.

Further findings

Proportion of association mediated by bystander cardiopulmonary resuscitation (CPR) rate (bayesian mediation analysis)

Average mediated proportion (95% QBCI 0.049-0.818; P = .01)
0.39
  • 39% of association mediated through increased bystander CPR rate

Original publication

Training in Basic Life Support and Bystander-Performed Cardiopulmonary Resuscitation and Survival in Out-of-Hospital Cardiac Arrests in Denmark, 2005 to 2019. JAMA Netw Open. Published 1 March 2023. doi:10.1001/jamanetworkopen.2023.3338

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