Perioperative medicine & outcomes
Transcranial Direct Current Stimulation for Anxiety During Laparoscopic Colorectal Cancer Surgery: A Randomized Clinical Trial
Primary result · Perioperative anxietyResult — go to the resultRelative risk 0.55 95% CI 0.42–0.73Authors' conclusion
Findings of this randomized clinical trial indicate that administration of 2 preoperative sessions of tDCS was associated with a decreased incidence of perioperative anxiety in patients undergoing elective CRC resection.
Study context
- Population
- Adults (≥18 years) undergoing elective laparoscopic radical resection for colorectal cancer
- Participants
- 196 adults
- Comparison
- Active transcranial direct current stimulation (tDCS) vs sham tDCS
- Active tDCSn = 98
- Sham tDCSn = 98reference
- Primary endpoint
- Incidence of perioperative anxiety (Hospital Anxiety and Depression Scale-Anxiety (HADS-A) subscale, range 0-21, higher = more anxiety)
- Follow-up
- From the day of the operation up to 3 days after the procedure
Methodological detailssham-controlled, single-centre, Conducted March to August 2023 at the Affiliated Hospital of Xuzhou Medical University
- Sham-controlled
- Single-centre
- Conducted March to August 2023 at the Affiliated Hospital of Xuzhou Medical University
Primary result
Perioperative anxiety · After the second tDCS intervention on the day of the operation
Relative risk
0.55
95% CI 0.42–0.73
P < 0.001
By group
Active tDCS vs Sham tDCS
RR 0.55 (95% CI 0.42–0.73); P < 0.001
As reported in the abstract
Secondary outcomes
Postoperative delirium
Median
| Outcome | Active tDCS | Sham tDCS |
|---|---|---|
| Pain (NRS) · 3 days after the operation | 1.0 (IQR 1.0–1.0) | 2.0 (IQR 2.0–2.0) |
| Sleep quality (PSQI) · 3 days after the operation | 10.5 (IQR 10.0–11.0) | 12.0 (IQR 11.0–13.0) |
| Frailty (FRAIL Index) · 3 days after the operation | 2.0 (IQR 1.0–2.0) | 2.0 (IQR 2.0–3.0) |
Original publication
Transcranial Direct Current Stimulation for Anxiety During Laparoscopic Colorectal Cancer Surgery: A Randomized Clinical Trial. JAMA Netw Open. Published 1 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →