Perioperative medicine & outcomes
Electroacupuncture vs Sham Electroacupuncture in the Treatment of Postoperative Ileus After Laparoscopic Surgery for Colorectal Cancer: A Multicenter, Randomized Clinical Trial
Primary result · Time to first defecationResult — go to the resultMean difference −8.76 95% CI −15.80 to −1.73Authors' conclusion
Results of this randomized clinical trial demonstrated that in patients undergoing laparoscopic surgery for colorectal cancer with the ERAS protocol, EA shortened the duration of POI and decreased the risk for prolonged POI compared with SA.
Study context
- Population
- Patients ≥18 y undergoing first laparoscopic resection of colorectal cancer within Enhanced Recovery After Surgery (ERAS) protocol, China248 analysed
- Participants
- 249 patients
- Comparison
- EA vs SA
- EAn = 125
- SAn = 123reference
- Primary endpoint
- Time to first defecation
Methodological detailsmulticentre, sham-controlled, 1:1 allocation, dynamic block randomisation, Central system randomisation, Conducted in China, October 12, 2020, through October 17, 2021
- Multicentre
- Sham-controlled
- 1:1 allocation
- Dynamic block randomisation
- Central system randomisation
- Conducted in China, October 12, 2020, through October 17, 2021
Primary result
As reported in the abstract
Mean difference
−8.76
95% CI −15.80 to −1.73
P = 0.003
By group
EA vs SA
mean difference −8.76 (95% CI −15.80 to −1.73); P = 0.003
Secondary outcomes
Time to first flatus
P < 0.001
Time to tolerability of semiliquid diet
P = 0.01
Time to tolerability of solid food
P = 0.01
| Outcome | EA | SA | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Prolonged POI | 10% | 20% | 0.51 (0.27–0.95) | P = 0.03 | |
| 0.20.5125Relative risk (log scale) |
Other secondary outcomes (LOS, 30-day readmission, complications)
- Not different between groups
Safety
- No severe adverse events
Original publication
Electroacupuncture vs Sham Electroacupuncture in the Treatment of Postoperative Ileus After Laparoscopic Surgery for Colorectal Cancer: A Multicenter, Randomized Clinical Trial. JAMA Surg. Published 1 January 2023. doi:10.
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